1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) Induces Cell Apoptosis of Human Mesangial Cells

In China, primary glomerulonephritis is the leading cause of end-stage renal disease (ESRD), and patients who require kidney transplantation often with ESRD. Glomerulonephritis primary’s most prevalent subtype Mesangial proliferative (MsPGN). Although cell apoptosis human mesangial cells (HMCs) may be harmful in MsPGN, it plays a major role elimination excessive HMCs reparative glomerular remodelling after inflammation. A powerful mitogen for growing epidermal growth factor (EGF). Therefore, possible to induce proliferation by incubating EGF vitro. 1,25(OH)2D3(VD3) death via activating AKT, caspase-3, caspase-9, JNK, ERK, as well elevating Bax Bad levels.